Container headspace moisture analysis is needed to ensure that the freeze drying process and the related system are efficient and are performing according the specifications.
It is recommended to operate moisture analysis both in product and process development, as well as during manufacturing to keep the maximum allowable moisture content monitored.
- Laser based headspace moisture analysis combines the advantages of being rapid, non-destructive an non-invasive for the product; therefore it helps improving the quality of finished product with a view on stability against headspace moisture.
- It is an excellent tool to characterize the efficiency of lyophilization cycles and the performance of freeze-drying in different locations within the freeze-dryer.
- The method is suitable both for performing moisture level inspection on 100% of the finished products and for monitoring moisture content of individual containers over the entire shelf life.