Headspace Carbon Dioxide Analysis
The non-destructive measurement of carbon dioxide level in the container headspace has many applications and there are several advantages associated.
- Where the filling process of a pharmaceutical product incorporates carbon dioxide, the headspace dedicated analysis provide an in-process-control monitoring of the CO2 levels.
- Moreover if cold storage on dry ice for transport is used as part of the process, headspace CO2 analysis can overcome the limits given by conventional container closure integrity, as various study results point out that leaking closures at a low temperature reseal themselves at ambient temperature.
- This method also replaces a container closure integrity verification if the method implemented is using carbon dioxide as a tracer gas.